BRAF Genetic Alteration Cell Panel (ATCC® TCP-1032)

Organism: Homo sapiens, human  / 

Organism Homo sapiens, human
Components ATCC CCL-224 COLO 201
ATCC CCL-238 SW1417
ATCC CRL-11147 A2058
ATCC CRL-1676 WM-266-4
ATCC CRL-2577 RKO
ATCC CRL-7898 A101D
ATCC HTB-123 DU4475
ATCC HTB-137 Hs 695T
ATCC HTB-66 RPMI-7951
Applications This validated panel is composed of 9 select human tumor cell lines carrying BRAF mutations, and is useful for BRAF pathway research and for anti-cancer drug discovery.
Biosafety Level 1
Comments

BRAF gene is a proto-oncogene encoding the BRAF protein, a serine/threonine kinase of the RAF family that acts downstream of RAS and upstream of MEK in the MAPK/ERK signaling pathway. BRAF mediates cell division, proliferation, and differentiation in response to a host of stimuli.  Mutations in BRAF lead to excessive cellular proliferation and enhanced survival, and often underlie birth defects, and cancers of the thyroid and skin.  The BRAF gene is most frequently mutated at codon 600.  BRAF V600E mutation has been found in more than 60% of melanomas, as well as 7-8% of other cancers. The BRAF Genetic Alteration Cell Panel (ATCC TCP-1032) is composed of nine selected human tumor cell lines from various common cancer types that carry BRAF hotspot mutations in codon 600.  The BRAF mutation status of each cell line has been sequenced and validated by ATCC.  This panel is useful for BRAF pathway research and BRAF inhibitors anti-cancer drug discovery.

Product Format 9 cryopreserved cell lines
Storage Conditions liquid nitrogen vapor phase (less than -130°C) only
Basic Documentation
Other Documentation
FAQs
  1. Tumor Cell Panels


    Date Updated: 3/27/2014

  2. Nucleic acids and cell pellets for ATCC Cell Panels


    Date Updated: 3/27/2014

  3. Molecular Signature Panels

    Date Updated: 3/27/2014
  4. Control cell line for tumor cell panels


    Date Updated: 3/27/2014

  5. Validated genetic information for tumor cell panels
    It depends on the types of panels. There are mainly two kinds ...
    Date Updated: 3/27/2014
  6. Tumor cell panels by tissue type vs. molecular signature


    Date Updated: 3/27/2014

  7. Tumor cell panels by tissue type


    Date Updated: 3/27/2014

  8. Gene mutation information for molecular signature panels


    Date Updated: 3/27/2014