ERK Genetic Alteration Cell Panel (ATCC® TCP-1033)

Organism: Homo sapiens, human  / 

Organism Homo sapiens, human
Components

ATCC CRL-2577 RKO
ATCC CRL-9446 CHL-1
ATCC HTB-111 AN3 CA
ATCC HTB-2 RT4
ATCC HTB-20 BT-474
ATCC HTB-65 MeWo
ATCC HTB-9 5637

Applications This validated panel is composed of 7 select human tumor cell lines carrying MAPK3 and MAPK1 gene mutations, and is useful for ERK pathway research and for anti-cancer drug discovery.
Biosafety Level 1
Comments ERK1 and ERK2 are important members of the mitogen-activated protein kinases (MAPKs) family, which controls a broad range of cellular activities and physiological processes, such as proliferation, cell survival, migration, morphology determination and oncogenic transformation. The MAPK1 gene encodes the ERK2 protein, and the MAPK3 gene encodes the ERK1 protein. ERK1/2 can be activated by upstream RAS-RAF-MEK signaling. Elevated and constitutive activation of ERK1/2 has been detected in various common cancer types. Mutations in the MAPK3 and MAPK1 genes have be observed in a subset of human tumors by next generation sequencing.

The ERK genetic alteration cell panel (ATCC TCP-1033) is composed of 7 selected human tumor cell lines from various common cancer types that carry COSMIC database validated mutations within MAPK1 and MAPK3 genes. This panel of cell lines also encompasses various basal levels of phosphor-ERK1/2. The MAPK1 and MAPK3 gene alteration status of each cell line has been sequenced and validated by ATCC.
Product Format 7 cryopreserved cell lines
Storage Conditions liquid nitrogen vapor phase (less than -130°C) only
Basic Documentation
Other Documentation
FAQs
  1. Tumor Cell Panels


    Date Updated: 3/27/2014

  2. Nucleic acids and cell pellets for ATCC Cell Panels


    Date Updated: 3/27/2014

  3. Molecular Signature Panels

    Date Updated: 3/27/2014
  4. Control cell line for tumor cell panels


    Date Updated: 3/27/2014

  5. Validated genetic information for tumor cell panels
    It depends on the types of panels. There are mainly two kinds ...
    Date Updated: 3/27/2014
  6. Tumor cell panels by tissue type vs. molecular signature


    Date Updated: 3/27/2014

  7. Tumor cell panels by tissue type


    Date Updated: 3/27/2014

  8. Gene mutation information for molecular signature panels


    Date Updated: 3/27/2014