MET Genetic Alteration Cell Panel (ATCC® TCP-1036)

Organism: Homo sapiens, human  / 

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Organism Homo sapiens, human
Components ATCC CRL-5973 SNU-5
ATCC HTB-135 Hs 746T
ATCC CRL-1585 C32
ATCC CRL-2351 AU565
ATCC CRL-5822 NCI-N87
Applications This validated panel is composed of 5 select human tumor cell lines carrying various degrees of MET gene copy number changes, and is useful for RAS pathway research and for anti-cancer drug discovery.
Biosafety Level 1
Comments

MET is a member of the tyrosine kinase receptor family, which leads signal transduction from the extracellular matrix into the cytoplasm after binding its ligang, hepatocyte growth factor (HGF).  The MET/HGF signaling pathway has been reported to be aberrantly activated in many human cancers, e.g., gastric cancer. In addition, amplification of MET correlates with poor prognosis, and plays a role in acquired resistance to EGFR inhibitors in patients with EGFR-mutant tumors.  

The MET Genetic Alteration Cell Panel (ATCC TCP-1036) is composed of five human tumor cells that carry various degrees of MET gene copy number changes.  The MET status of each cell line has been validated by ATCC.  This panel is useful for studying bio-functions of MET and MET amplification, as well as tyrosine kinase inhibitor anti-cancer drug discovery.

Product Format 5 cryopreserved cell lines
Storage Conditions liquid nitrogen vapor phase (less than -130°C) only
Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation
Other Documentation
FAQs
  1. Tumor Cell Panels


    Date Updated: 3/27/2014

  2. Nucleic acids and cell pellets for ATCC Cell Panels


    Date Updated: 3/27/2014

  3. Molecular Signature Panels

    Date Updated: 3/27/2014
  4. Control cell line for tumor cell panels


    Date Updated: 3/27/2014

  5. Validated genetic information for tumor cell panels
    It depends on the types of panels. There are mainly two kinds ...
    Date Updated: 3/27/2014
  6. Tumor cell panels by tissue type vs. molecular signature


    Date Updated: 3/27/2014

  7. Tumor cell panels by tissue type


    Date Updated: 3/27/2014

  8. Gene mutation information for molecular signature panels


    Date Updated: 3/27/2014