Acremonium chrysogenum (Thirumalachar et Sukapure) Gams, anamorph (ATCC® 11550)

Strain Designations: [CBS 779.69, DSM 880, IMI 49137]  /  Product Format: freeze-dried

Permits and Restrictions

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Strain Designations [CBS 779.69, DSM 880, IMI 49137]
degrades cassava
produces alkaline protease
produces cephalosporin C
produces cephalosporin P
produces deacetoxycephalosporin C
produces penicillin N adicillin, cephalosporin N, isopenicillin N, synnematin B
produces protease nonstructural protein 3
produces single-cell protein SCP
transformation host
produces single-cell protein from cassava
transformation host for expression of Fusarium alkaline protease gene
Biosafety Level 1
Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain no
Preceptrol® no
Genome Sequenced Strain


Virus-like particles
Polymorphic karyotype
Genome sequencing strain (China state institute of pharmaceutical industry, China)
Medium ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 335: Potato carrot agar
ATCC® Medium 336: Potato dextrose agar (PDA)
Growth Conditions
Temperature: 24°C to 26°C
Atmosphere: Typical aerobic
Sequenced Data
No DNA sequencing was performed in house on this product.
Name of Depositor NG Heatley
Chain of Custody
ATCC <-- NG Heatley <-- G. Brotzu (Cephalosporium chrysogenum)
Seawater, Sardinia, Italy
Cross References

Nucleotide (GenBank) : X82163 A.chrysogenum ACP1 promoter DNA.

Nucleotide (GenBank) : X82164 A.chrysogenum ACP2 promoter DNA.

Nucleotide (GenBank) : U17426 Acremonium chrysogenum large subunit ribosomal RNA, partial

Nucleotide (GenBank) : X15937 Cephalosporium acremonium pyr4 gene for orotidine-5'-phosphate


Nakao Y, et al. Production of deacetoxycephalosporin C. US Patent 3,979,260 dated Sep 7 1976

Morita S, et al. Secretion of active human lysozyme by Acremonium chrysogenum using a Fusarium alkaline protease promoter system. J. Biotechnol. 42: 1-8, 1995. PubMed: 7662338

Walz M, Kuck U. Polymorphic karyotypes in related Acremonium strains. Curr. Genet. 19: 73-76, 1991. PubMed: 1676616

. . J. Ferment. Technol. 55: 27-36, 1977.

Hoskins JA, et al. Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremonium. Curr. Genet. 18: 523-530, 1990. PubMed: 2076552

Morita S, et al. High level expression of Fusarium alkaline protease gene in Acremonium chrysogenum. Biosci. Biotechnol. Biochem. 58: 627-630, 1994. PubMed: 7764854

Day LE, Ellis LF. Virus-like particles in Cephalosporium acremonium. Appl. Microbiol. 22: 919-920, 1971. PubMed: 4108900

Isogai T, et al. Cloning and nucleotide sequences of the complementary and genomic DNAs for the alkaline protease from Acremonium chrysogenum. Agric. Biol. Chem. 55: 471-477, 1991. PubMed: 1368696

Yagi J, et al. Studies on alkaline proteinase from Cephalosporium. I. Purification of the enzyme. J. Ferment. Technol. 50: 592-599, 1972.

Yagi J, et al. Alkaline proteinase from Cephalosporium sp. II. Enzymatic properties of the alkaline proteinase. J. Ferment. Technol. 50: 810-815, 1972.

Yagi J, et al. Alkaline proteinase from Cephalosporium sp. III. Physiochemical properties of the enzyme. J. Ferment. Technol. 50: 816-822, 1972.

Yagi J, et al. Production of protease by Cephalosporium sp. in a pilot plant. J. Ferment. Technol. 53: 99-102, 1975.

Gregory KF. Feed enrichment with microbial protein. Conserv. Recycl. 5: 33-40, 1982.

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation