EGFR Genetic Alteration Cell Panel (ATCC® TCP-1027)

Organism: Homo sapiens, human  / 

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Organism Homo sapiens, human
Components ATCC CRL-2868 HCC827
ATCC CRL-2871 HCC4006
ATCC CCL-231 SW48
ATCC CRL-5908 NCI-H1975
ATCC HTB-132 MDA-MB-468
ATCC HTB-19 BT-20
ATCC HTB-178 NCI-H596
ATCC HTB-177 NCI-H460
ATCC CRL-5928 NCI-H2170
ATCC HTB-20 BT-474
ATCC HTB-27 MDA-MB-361
Applications This panel is useful for EGFR pathway research and for anti-cancer drug discovery.
Biosafety Level 1
Comments EGFR/ERBB1/HER1 and ERBB2/EGFR2/HER2 are members of the ErbB super family of receptor tyrosine kinases. These receptors bind multiple EGF family-member ligands to initiate signaling cascades critical for an array of cellular processes, such as proliferation, differentiation, survival, metabolism, and migration. EGFR and ERBB2 are targets of an expanding class of anticancer therapies. The most common mutations associated with sensitivity to EGFR inhibitors include exon 19 deletions and the L858R point mutation.  Conversely, the EGFR T790M Mutation has been linked to drug resistance.  

The EGFR genetic alteration cell panel (ATCC TCP-1027) is composed of eleven human tumor cell lines from various common cancer types that carry hotspot mutations or gene copy number amplification within the EGFR or ERBB2 gene. The EGFR and ERBB2 status of each cell line has been sequenced and validated by ATCC. This panel is useful for EGFR pathway research and for anti-cancer drug discovery.

Product Format frozen
Storage Conditions LN vapor (less than -130°C) only
Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation
Other Documentation
FAQs
  1. Tumor Cell Panels


    Date Updated: 3/27/2014

  2. Molecular Signature Panels

    Date Updated: 3/27/2014
  3. Tumor cell panels by tissue type


    Date Updated: 3/27/2014

  4. Tumor cell panels by tissue type vs. molecular signature


    Date Updated: 3/27/2014

  5. Validated genetic information for tumor cell panels
    It depends on the types of panels. There are mainly two kinds ...
    Date Updated: 3/27/2014
  6. Control cell line for tumor cell panels


    Date Updated: 3/27/2014

  7. Gene mutation information for molecular signature panels


    Date Updated: 3/27/2014

  8. Nucleic acids and cell pellets for ATCC Cell Panels


    Date Updated: 3/27/2014