EGFR Genetic Alteration Cell Panel

TCP-1027 ^™

EGFR/ERBB1/HER1 and ERBB2/EGFR2/HER2 are members of the ErbB super family of receptor tyrosine kinases. These receptors bind multiple EGF family-member ligands to initiate signaling cascades critical for an array of cellular processes, such as proliferation, differentiation, survival, metabolism, and migration. EGFR and ERBB2 are targets of an expanding class of anticancer therapies. The most common mutations associated with sensitivity to EGFR inhibitors include exon 19 deletions and the L858R point mutation. Conversely, the EGFR T790M Mutation has been linked to drug resistance.

The EGFR genetic alteration cell panel (ATCC TCP-1027) is composed of eleven human tumor cell lines from various common cancer types that carry hotspot mutations or gene copy number amplification within the EGFR or ERBB2 gene. The EGFR and ERBB2 status of each cell line has been sequenced and validated by ATCC. This panel is useful for EGFR pathway research and for anti-cancer drug discovery.

Components: ATCC CRL-2868 HCC827
ATCC CRL-2871 HCC4006
ATCC CCL-231 SW48
ATCC CRL-5908 NCI-H1975
ATCC HTB-132 MDA-MB-468
ATCC HTB-19 BT-20
ATCC HTB-178 NCI-H596
ATCC HTB-177 NCI-H460
ATCC CRL-5928 NCI-H2170
ATCC HTB-20 BT-474
ATCC HTB-27 MDA-MB-361
Product format: Frozen
Storage conditions: Vapor phase of liquid nitrogen

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Documentation

Product sheet

Instructions for use

BSL 1

ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

ATCC highly recommends that appropriate personal protective equipment is always used when handling vials. For cultures that require storage in liquid nitrogen, it is important to note that some vials may leak when submersed in liquid nitrogen and will slowly fill with liquid nitrogen. Upon thawing, the conversion of the liquid nitrogen back to its gas phase may result in the vial exploding or blowing off its cap with dangerous force creating flying debris. Unless necessary, ATCC recommends that these cultures be stored in the vapor phase of liquid nitrogen rather than submersed in liquid nitrogen.

General

Specific applications: This panel is useful for EGFR pathway research and for anti-cancer drug discovery.

Characteristics

Comments: EGFR/ERBB1/HER1 and ERBB2/EGFR2/HER2 are members of the ErbB super family of receptor tyrosine kinases. These receptors bind multiple EGF family-member ligands to initiate signaling cascades critical for an array of cellular processes, such as proliferation, differentiation, survival, metabolism, and migration. EGFR and ERBB2 are targets of an expanding class of anticancer therapies. The most common mutations associated with sensitivity to EGFR inhibitors include exon 19 deletions and the L858R point mutation. Conversely, the EGFR T790M Mutation has been linked to drug resistance.

The EGFR genetic alteration cell panel (ATCC TCP-1027) is composed of eleven human tumor cell lines from various common cancer types that carry hotspot mutations or gene copy number amplification within the EGFR or ERBB2 gene. The EGFR and ERBB2 status of each cell line has been sequenced and validated by ATCC. This panel is useful for EGFR pathway research and for anti-cancer drug discovery.

Legal disclaimers

Intended use

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

Warranty

The product is provided 'AS IS' and the viability of ATCC^® products is warranted for 30 days from the date of shipment, provided that the customer has stored and handled the product according to the information included on the product information sheet, website, and Certificate of Analysis. For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. While other unspecified media and reagents may also produce satisfactory results, a change in the ATCC and/or depositor-recommended protocols may affect the recovery, growth, and/or function of the product. If an alternative medium formulation or reagent is used, the ATCC warranty for viability is no longer valid. Except as expressly set forth herein, no other warranties of any kind are provided, express or implied, including, but not limited to, any implied warranties of merchantability, fitness for a particular purpose, manufacture according to cGMP standards, typicality, safety, accuracy, and/or noninfringement.

Disclaimers

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

This product is sent on the condition that the customer is responsible for and assumes all risk and responsibility in connection with the receipt, handling, storage, disposal, and use of the ATCC product including without limitation taking all appropriate safety and handling precautions to minimize health or environmental risk. As a condition of receiving the material, the customer agrees that any activity undertaken with the ATCC product and any progeny or modifications will be conducted in compliance with all applicable laws, regulations, and guidelines. This product is provided 'AS IS' with no representations or warranties whatsoever except as expressly set forth herein and in no event shall ATCC, its parents, subsidiaries, directors, officers, agents, employees, assigns, successors, and affiliates be liable for indirect, special, incidental, or consequential damages of any kind in connection with or arising out of the customer's use of the product. While reasonable effort is made to ensure authenticity and reliability of materials on deposit, ATCC is not liable for damages arising from the misidentification or misrepresentation of such materials.

Please see the material transfer agreement (MTA) for further details regarding the use of this product. The MTA is available at www.atcc.org.

Permits & Restrictions

For-profit Research Use License from MD Anderson Cancer Center

For-profit Organizations: For every order of this item, you must work directly with the contributor, MD Anderson Cancer Center to (i) negotiate a research-use license, and/or (ii) have the contributor provide authorization to ATCC to ship this item under your existing license. We cannot ship this item until we receive communication directly from MD Anderson Cancer Center that we are authorized to ship each order.

We are providing the following contact information, but this information may change without notice:
M.D. Anderson Cancer Center
Office of Technology Commercialization
Email: [email protected]

Once ATCC has received authorization from MD Anderson Cancer Center, your order will be reviewed, and this item will be released for shipment if all requirements are met. If you need assistance with your order, please contact our Customer Care team or your applicable distributor.

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.

MORE INFORMATION ABOUT PERMITS AND RESTRICTIONS

References

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