Subscribe
Date
Past
2012
2013
2014
2015
2016
2017
2018
2019
Upcoming

Cedarlane Expo 2019

9th Annual Expo

5/23/2019

Toronto Ontario

Join us at the 9th annual Cedarlane Life Science & Medical Lab Expo to can see what’s new in your area of research and chat with industry experts.

Luis Rodriguez, Ph.D., and Kevin Grady, B.S., are adept at developing cell-based assays that incorporate immortalized primary cells. Join this webinar to hear Dr. Rodriguez and Mr. Grady cover these topics:

  • hTERT-immortalized primary cells are comparable to primary cells regarding physiological relevance, but without the limitation of proliferation.
  • Using well-characterized hTERT-immortalized cells, ATCC has created credible cell models for toxicological studies on the kidney, skin, airway, and vasculature.
  • Our data show that these modified cell lines are effective tools that provide tissue-relevant results and reproducibility for any cell-based assay, including toxicology assays.

Dr. Elizabeth Gillies is well-versed in using CRISPR/Cas9 genome-editing technology for creating cell-based models with disease-relevant mutations. Watch the presentation to learn how this advanced technology was used to introduce a specific point mutation that confers drug resistance into the A375 melanoma line. Dr. Gillies will present data indicating that this isogenic cell line is resistant to both MEK and BRAF inhibitors and sensitive to combination therapies targeting both upstream and downstream elements of the Ras/Raf-MAPK signaling pathway.

Key Points:

  • CRISPR/Cas9 genome engineering was used to create a series of isogenic cell-based models of drug-resistant melanoma.
  • The new A375 MEK1 Q56P melanoma model is resistant to BRAF and MEK inhibitors currently used in melanoma treatment, making it an ideal model for the development of novel therapeutics and combination therapies.
  • A375 drug-resistant melanoma models can be used for screening or study of novel therapeutics in either the traditional 2D tissue culture format or as 3D spheroids that more closely mimic the biological tumor micro-environment.

ASM Microbe 2019

American Society for Microbiology

6/20/2019 — 6/24/2019

San Francisco CA

Booths #1150 & #1156

ASM Microbe 2019 showcases the best microbial sciences in the world, and provides a one-of-a-kind forum to explore the complete spectrum of microbiology from basic science to translation and application.

ASV Annual Meeting 2019

American Society for Virology

7/20/2019 — 7/24/2019

Minneapolis MN

The American Society for Virology (ASV) invites you to participate in the 38th Annual Meeting to be hosted and held at the University of Minnesota. This annual meeting is designed to promote discussion and collaboration among scientists active in all aspects of virology.

AMP 2019 Annual Meeting & Expo

Association for Molecular Pathology

11/7/2019 — 11/9/2019

Baltimore MD

Booth #2852

AMP 2019 brings together key researchers in every aspect of molecular diagnostics, including interpretation and reporting of molecular diagnostic tests; assay development, validation, and performance; and translational research.

ASTMH 68th Annual Meeting 2019

American Society of Tropical medicine & Hygiene

11/20/2019 — 11/24/2019

National Harbor MD

The ASTMH Annual Meeting is a five-day educational conference that draws nearly 4,500 attendees—researchers, physicians in global health and tropical & travel disease, military personnel, and public health officials from around the world.