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Amplify Your Viral Vaccine Production

Amplify Your Viral Vaccine Production with CRISPR/Cas9-Engineered Host Cells

Vaccines against viral infections like polio, chickenpox, measles, and viral hepatitis are manufactured by producing large quantities of viral particles in a scaled-up tissue culture system. A handful of historical cell lines like Vero (green monkey kidney) and MDCK (canine kidney) are approved by the FDA for viral vaccine production. However, other than clone selection and substrate adaption, relatively little has been done to improve the inherent viral production capacity of the cell lines. ATCC used CRISPR/Cas9 gene editing to create improved versions of cell lines commonly used for viral vaccine manufacturing. These cells produce model clinical viruses at titers 10-fold higher than the corresponding parental cell line, which has the potential to significantly reduce costs associated with virus and viral vaccine production.


Cell Lines for Enhanced Virus Production

The continual spread of deadly viruses necessitates the development of novel prevention and treatment options. However, the development of a new antiviral vaccine can be challenged by low-yielding manufacturing processes. To address this, ATCC used cutting-edge CRISPR/Cas9 gene-editing technology to develop STAT1 knockout cell lines capable of producing high-titer viral stocks. Discover how these advanced biological models can be used in your vaccine development research.