Angiogenesis is critical to maintaining the circulation of blood to and from the cells of the body. ATCC provides primary cell cultures, cell lines, and assay-ready kits to aid in the study of angiogenesis.

In angiogenesis, new vasculature sprouts from existing blood vessels. This process occurs naturally during growth and healing; it provides newly formed or repaired tissues with a consistent blood flow for the delivery of gasses and nutrients as well as the removal of waste products. Tumors take advantage of this process by secreting vascular growth factors, causing excessive blood vessels to grow into the tumor. By contrast, in coronary artery disease, stroke, and chronic wounds there is an insufficiency of blood vessel growth. Moreover, in diseases such as diabetes, both exaggerated and inadequate angiogenesis may occur in the same patient. To support angiogenesis research, ATCC offers:

• An assay-ready, high-throughput angiogenesis kit
• hTERT-immortalized endothelial cells and mesenchymal stem cells
• Cell matrix gels to support angiogenic tubule formation
• Primary vascular endothelial and smooth muscle cells

These products support the formation of vascular structures in vitro, which may be used to investigate disease pathogenesis, employed in toxicological screening assays, or for drug development studies.