FGFR Genetic Alteration Cell Panel (ATCC® TCP-1034)

Organism: Homo sapiens, human  / 

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Organism Homo sapiens, human
Components ATCC HTB-23 MDA-MB-134-VI
ATCC CRL-2066 DMS 114
ATCC CCL-235 SW837
ATCC CRL-5974 SNU-16
Applications This validated panel is composed of 8 select human cancer cell lines carrying various degrees of FGFR1 and FGFR2 amplification, and is useful for FGFR pathway research and for anti-cancer drug discovery.
Biosafety Level 2  [Cells contain Parainfluenza virus type 5]

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.


Fibroblast Growth Factor Receptors (FGFRs), are transmembrane tyrosine kinase receptors that induce intracellular tyrosine kinase activity when bound to Fibroblast Growth Factor.  FGFR plays crucial roles in development and cell growth. Upregulation of the FGF/FGFR signaling pathway leads to induction of mitogenic and survival signals, as well as promoting epithelial-mesenchymal transition, invasion and tumor angiogenesis. Amplification or activation of FGFR1 and FGFR2 genes has been linked to several cancer types such as lung cancer, breast cancer and gastric cancer. 

The FGFR genetic alteration cell panel (ATCC TCP-1034) is composed of eight selected human tumor cell lines from common cancer types that carry various gene copy number amplification within the FGFR1 or FGFR2 genes. The FGFR1 or FGFR2 status of each cell line has been validated by ATCC. This panel is useful for FGFR pathway research and FGFR inhibitors anti-cancer drug discovery.

Product Format 8 cryopreserved cell lines
Storage Conditions liquid nitrogen vapor phase (less than -130°C) only
Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • For-profit customers must obtain a research use license agreement from the Contributor prior to shipment.
  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
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Unless the Purchaser has a separate license agreement with The University of Texas M. D. Anderson Cancer Center (“Institution”), the ATCC Material is subject to the following restrictions:

  1. The ATCC Material (and any Modifications, Unmodified Derivatives and/or Progeny thereof) may not be used (1) for commercial purposes or Commercial Use by any Purchaser, or (2) by for-profit or commercial entities for any purpose;
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The restrictions set forth above are in addition to the restrictions set forth in the ATCC Material Transfer Agreement. Capitalized terms have the meanings set forth in the ATCC Material Transfer Agreement unless otherwise indicated above.

For instructions on how to obtain a license from Institution, please contact John B. Scott, Ph.D. at the Institution Office of Technology Commercialization via email at jscott3@mdanderson.org.