Aspergillus ochraceus Wilhelm, anamorph (ATCC® 18500)

Strain Designations: NRRL 405 [4718]  /  Product Format: freeze-dried

Permits and Restrictions

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Strain Designations NRRL 405 [4718]
hydroxylates 11,13-dehydrosantonin
oxidizes chrysanthemol
produces 11-alpha-hydroxyprogesterone
produces L-malic acid
produces Reichstein's compound S
produces succinic acid
transforms flavonoids
oxidizes chrysanthemols to chrysanthemic acids
transformation of: sesquiterpene lactone costunolide
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Type Strain no
Preceptrol® no
Medium ATCC® Medium 312: Czapek's agar
Growth Conditions
Temperature: 24.0°C
Name of Depositor NRRL
Chain of Custody
ATCC <<--NRRL<<--C. Thom 4718
rubber sheet

Singh K, et al. Large-scale transformation of steroids by fungal spores. Appl. Microbiol. 16: 393-400, 1968. PubMed: 5645421

Sehgal SN, et al. 11 alpha-hydroxylation of steroids by spores of Aspergillus ochraceus. Can. J. Microbiol. 14: 529-532, 1968. PubMed: 5665975

Miski M, Davis PJ. Microbiologically catalyzed enantio- and diastereoselective oxidation of chrysanthemol stereoisomers to chrysanthemic acids. Appl. Environ. Microbiol. 54: 2268-2272, 1988.

Bercovitz A, et al. Localization of pyruvate carboxylase in organic acid-producing Aspergillus strains. Appl. Environ. Microbiol. 56: 1594-1597, 1990. PubMed: 2383004

Iida M, et al. Microbial hydroxylation of 11,13-dehydrosantonin by Aspergillus niger. J. Ferment. Bioeng. 76: 296-299, 1993.

Ibrahim AR, Abul-Hajj YJ. Microbiological transformation of flavone and isoflavone. Xenobiotica 20: 363-373, 1990. PubMed: 2346033

Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979.

Madyastha KM, et al. Studies on the microsomal 11alpha-hydroxylation of progesterone in Aspergillus ochraceus: isolation, characterization, and solubilization of the hydroxylase system. Can. J. Biochem. Cell Biol. 62: 100-107, 1984.

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation