Acremonium chrysogenum (Thirumalachar et Sukapure) Gams (ATCC® 11550)

Strain Designations: [CBS 779.69, DSM 880, IMI 49137]  /  Product Format: freeze-dried

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Deposited As Acremonium chrysogenum (Thirumalachar et Sukapure) Gams, anamorph
Strain Designations [CBS 779.69, DSM 880, IMI 49137]
Degrades cassava
Produces alkaline protease
Produces cephalosporin C
Produces cephalosporin P
Produces deacetoxycephalosporin C
Produces penicillin N adicillin, cephalosporin N, isopenicillin N, synnematin B
Produces protease nonstructural protein 3
Produces single-cell protein SCP
Transformation host
Produces single-cell protein from cassava
Transformation host for expression of Fusarium alkaline protease gene
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain no
Preceptrol® no
Genome Sequenced Strain


Virus-like particles
Polymorphic karyotype
Genome sequencing strain (China state institute of pharmaceutical industry, China; Ruhr-Universitaet Bochum, Germany)
Medium ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 335: Potato carrot agar
ATCC® Medium 336: Potato dextrose agar (PDA)
Growth Conditions
Temperature: 24°C to 26°C
Atmosphere: Typical aerobic
Sequenced Data
No DNA sequencing was performed in house on this product.
Name of Depositor NG Heatley
U.S. Patent Number 3,979,260
Chain of Custody
ATCC <-- NG Heatley <-- G. Brotzu (Cephalosporium chrysogenum)
Seawater, Sardinia, Italy
Cross References

Nucleotide (GenBank) : X82163 A.chrysogenum ACP1 promoter DNA.

Nucleotide (GenBank) : X82164 A.chrysogenum ACP2 promoter DNA.

Nucleotide (GenBank) : U17426 Acremonium chrysogenum large subunit ribosomal RNA, partial

Nucleotide (GenBank) : X15937 Cephalosporium acremonium pyr4 gene for orotidine-5'-phosphate

Nucleotide (GenBank) : JPKY00000000 Acremonium chrysogenum ATCC 11550, whole genome shotgun sequencing project


Terfehr D, et al. Genome sequence and annotation of Acremonium chrysogenum, producer of the beta-lactam antibiotic cephalosporin C. Genome Announc 2(5). pii: e00948-14, 2014. PubMed: 25291769

Gsaller F, et al. The first promoter for conditional gene expression in Acremonium chrysogenum: iron starvation-inducible mir1(P). J Biotechnol 163: 77-80, 2013. PubMed: 23089729

Morita S, et al. Secretion of active human lysozyme by Acremonium chrysogenum using a Fusarium alkaline protease promoter system. J. Biotechnol. 42: 1-8, 1995. PubMed: 7662338

Morita S, et al. High level expression of Fusarium alkaline protease gene in Acremonium chrysogenum. Biosci. Biotechnol. Biochem. 58: 627-630, 1994. PubMed: 7764854

Walz M, Kuck U. Polymorphic karyotypes in related Acremonium strains. Curr Genet 19: 73-76, 1991. PubMed: 1676616

Isogai T, et al. Cloning and nucleotide sequences of the complementary and genomic DNAs for the alkaline protease from Acremonium chrysogenum. Agric. Biol. Chem. 55: 471-477, 1991. PubMed: 1368696

Hoskins JA, et al. Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremonium. Curr. Genet. 18: 523-530, 1990. PubMed: 2076552

Gregory KF. Feed enrichment with microbial protein. Conserv. Recycl. 5: 33-40, 1982.

Kitano K, Kintaka K, Nakao Y. Comparative study of methionine effect on cephalosporin production by various fungi. J Ferment Technol 55: 27-36, 1977.

Day LE, Ellis LF. Virus-like particles in Cephalosporium acremonium. Appl. Microbiol. 22: 919-920, 1971. PubMed: 4108900

Yagi J, et al. Studies on alkaline proteinase from Cephalosporium. I. Purification of the enzyme. J. Ferment. Technol. 50: 592-599, 1972.

Yagi J, et al. Alkaline proteinase from Cephalosporium sp. II. Enzymatic properties of the alkaline proteinase. J. Ferment. Technol. 50: 810-815, 1972.

Yagi J, et al. Alkaline proteinase from Cephalosporium sp. III. Physiochemical properties of the enzyme. J. Ferment. Technol. 50: 816-822, 1972.

Yagi J, et al. Production of protease by Cephalosporium sp. in a pilot plant. J. Ferment. Technol. 53: 99-102, 1975.

Nakao Y, et al. Production of deacetoxycephalosporin C. US Patent 3,979,260 dated Sep 7 1976

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation