Antibody Class: IgG2aκ
The B cell hybridoma was generated by the fusion of P3X63.Ag8.53 BALB/c mouse myeloma cells with immunized mouse splenocytes. The clone E18 antibody is reported to bind to the fusion loop of domain II in the envelope glycoprotein.
Functional activity is confirmed by reactivity in immunofluorescence assays using Vero cells (ATCC® CCL-81™) infected with WNV and by ELISA using WNV-infected cell lysates [WNV, Eg101 (Egypt 1951)]. The antibody has been reported to be non-neutralizing, or weakly neutralizing and reactive using flow cytometry and Western blot analysis.