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Murine hepatitis virus (ATCC® VR-261™)

Classification: Nidovirales, Coronaviridae, Coronavirus,Group 2  /  Product Format: frozen

Classification Nidovirales, Coronaviridae, Coronavirus,Group 2
Agent Murine hepatitis virus
Strain MHV 1 (Parkes)
Common Name Murine hepatitis virus
Applications
Produces little evidence of infection in otherwise healthy weanling mice.
This virus is fairly stable when lyophilized and stored at 4C. Such lyophilized seed preparations should not be used directly for experiments.
Biosafety Level 2

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Isolation
Liver and kidney tissues from ill mice, 1950, London
Product Format frozen
Storage Conditions -70°C or colder
Comments
Related to MHV-3, Nelson's PR 1 (MHV-2), JHM, Morris' agents EHF120 and M747 and MHV-A59 of Manaker, et al. Produces little evidence of infection in otherwise healthy weanling mice.
This virus is fairly stable when lyophilized and stored at 4C. Such lyophilized seed preparations should not be used directly for experiments. Mice infected with MHV-1 AND Eperythrozoon coccoides develop fatal hepatitis.
Effect on Host
Cytopathic effects in tissue culture
death in newborn mice
Recommended Host
neonatal mice
suckling mouse; NCTC clone 1469 (ATCC CCL-9.1)
Growth Conditions
Incubation: 4-7 days
Effect on Host
Cytopathic effects in tissue culture
death in newborn mice
Name of Depositor MJ Collins, AW Gledhill
Special Collection ATCC
Source
Liver and kidney tissues from ill mice, 1950, London
Year of Origin 1950
References

Piczak CV, et al. A hepatitis virus complicating studies with mouse leukemia. J. Natl. Cancer Inst. 27: 29-51, 1961. PubMed: 13766009

Gledhill AW, Andrewes CH. A hepatitis virus of mice. Br. J. Exp. Pathol. 32: 559-568, 1951. PubMed: 4895796

Morris JA. A new member of hepato-encephalitis group of murine viruses. Proc. Soc. Exp. Biol. Med. 100: 875-877, 1959. PubMed: 13645751