Cells are immortalized MEFs, which were generated from BAK knockout mice.
Cells are immortalized MEFs (genotype: bak-/-), which were generated from BAK knockout mice.
Cells are sensitive to tBID-induced cytochrome c release and apoptosis.
Cells are sensitive to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Cells are sensitive to Bim and Bad expression induced apoptosis.
BAK is a pro-apoptotic BCL-2 family member.
This cell line is useful for studying molecular mechanism of cell apoptosis, BCL-2 family pathway, BAK function, as well as cells that are resistant to multiple apoptotic stimuli.