References
Wieser M, et al. hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. Am. J. Physiol. Renal Physiol. 295: 1365-1375, 2008. PubMed: 18715936
Bodnar AG, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352, 1998. PubMed: 9454332
Freshney RI. Culture of Animal Cells: A Manual of Basic Technique, 5th edition. New York: Wiley Liss; 2005. For more information on enzymatic dissociation and subculturing of cell lines see Chapter 13.
Limonciel A, et al. Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol 92(8):2517-2531, 2018. PubMed: 30008028
Simon-Friedt BR, et al. The RPTEC/TERT1 Cell Line as an Improved Tool for In Vitro Nephrotoxicity Assessments. Biol Trace Elem Res 166(1):66-71, 2015. PubMed: 25893367
Aschauer L, et al. Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1. Toxicol In Vitro 30(1 Pt A):95-105, 2015. PubMed: 25500123
Simon BR, et al. The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium. Toxicol Rep 1:231-242, 2014. PubMed: 25126521
Secker PF, et al. RPTEC/TERT1 cells form highly differentiated tubules when cultured in a 3D matrix. ALTEX 35(2):223-234, 2017. PubMed: 29197217
Shrestha S, et al. Human renal tubular cells contain CD24/CD133 progenitor cell populations: Implications for tubular regeneration after toxicant induced damage using cadmium as a model. Toxicol Appl Pharmacol 331:116-129, 2017. PubMed: 28587817
Simon BR, et al. Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line. Toxicol Rep 1:391-400, 2014. PubMed: 25170436
Soodvilai S, et al. Interaction of pharmaceutical excipients with organic cation transporters. Int J Pharm 520(1-2):14-20, 2017. PubMed: 28131852
Shah H, et al. Gene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction. Xenobiotica 47(10):837-843, 2017. PubMed: 27616666
Kramer NI, et al. Biokinetics in repeated-dosing in vitro drug toxicity studies. Toxicol In Vitro 30(1 Pt A):217-24, 2015. PubMed: 26362508
Aschauer L, et al. Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study. Toxicol In Vitro 30(1 Pt A):106-16, 2015. PubMed: 25450743
Wilmes A, et al. Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol in Vitro 30(1 Pt A):117-27, 2015. PubMed: 25450742
Wilmes A, et al. Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress. J Proteomics V79:180-194, 2013. PubMed: 23238060
Wilmes A, et al. Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol 279(2):163-72, 2014. PubMed: 24907557
Jennings P, et al. Interleukin-19 as a translational indicator of renal injury. Arch Toxicol 89(1):101-6, 2015. PubMed: 24714768
Ranninger C, et al. Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline. J Biol Chem 290(31): 19121-32, 2015 PubMed: 26055719