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IDH2 mutant-TF-1 Isogenic Cell Line ATCC CRL-2003IG

What type of mutation does the IDH2 mutant-TF-1 Isogenic Cell Line (ATCC® CRL-2003IG ™) contain and how was this line created?  

ATCC® CRL-2003IG ™ contains a homozygous knock-in mutation at position c.419G>A, p.R140Q generated from the parental TF-1 (ATCC® CRL-2003) human acute myeloid leukemia cell line. This mutant isogenic line was generated using the CRISPR/Cas9 system followed by single cell cloning and validation.

Date Created10/03/2017 12:01 PM
Date Updated10/03/2017 12:02 PM

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