Finding Your Perfect Match

Evolving Technologies for Bacterial Strain Typing

3/9/2017


Time: 12:00 PM Eastern Standard Time

Abstract:

Bacterial strains within the same species can show a wide range of genetic differences, from only a few nucleotides to large chromosomal variations. Identifying specific strains can provide important clues to antimicrobial resistance or virulence factors, and is central to epidemiological studies of disease outbreaks. In this webinar, we will look at the variety of typing information used to identify strains in the ATCC catalog. From traditional serological methods to various electrophoresis-based molecular methods and the latest applications of whole genome sequencing, we will discuss these technologies, their applications in current literature, and how ATCC is working to improve strain typing by providing quality control and reference materials.

Key Points

  • The amount and type of strain difference within a given species of bacteria can differ widely and has given rise to a variety of strain typing technologies
  • Molecular methods have become predominant and have evolved from primarily electrophoresis-based methods, such as pulsed-field gel electrophoresis, to sequence-based methods, such as those based on one or more loci
  • Whole genome sequencing offers great promise for future typing as it offers both high resolution and the power of examining many loci, but comes with challenges in terms of quality control and data management

Presenters

Brian Cantwell

Brian Cantwell, Ph.D.,
Scientist, ATCC

Dr. Cantwell has been with ATCC for three years and is the Microbiology Scientist with the ATCC’s Central Accessioning Unit. He has a Ph.D. in Microbiology and has worked in the fields of bacterial pathogenesis, bacterial chemotaxis, microbial genetics, and biochemistry using both laboratory and bioinformatics approaches.