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Neural Progenitor Cells – Potent Models of Normal and Disease Neurobiology

Neural Progenitor Cells – Potent Models of Normal and Disease Neurobiology

In vitro,/em> neurological research presents many challenges due to the difficulty in establishing high-yield neuronal cultures as well as batch-to-batch consistency. Human induced pluripotent stem cells (iPSCs) have a high expansion capacity and can differentiate into neurological cells types; thus, these cells hold great promise for both regenerative medicine and drug discovery. This webinar will discuss neural differentiation and touch on its roles in investigating neurodegenerative diseases and screening therapeutics. Methods for generating large quantities of neural progenitor cells (NPCs) from human fibroblast-, CD34+-, and Parkinson’s disease-derived iPSCs will then be highlighted. Finally, the generation and function of NPC reporter cell lines, created using zinc finger nuclease gene editing technology, will be examined.