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CRISPR-edited Isogenic Cell Models Video

CRISPR/Cas9 genome editing technology is one of the most outstanding scientific breakthroughs in recent years, revolutionizing basic and medical research by enabling site-specific genome engineering of cell lines.

ATCC has mastered the science and art of CRISPR gene-editing. We take highly authenticated cell lines from our collection and introduce disease-relevant mutations using the CRISPR/Cas9 system to modify regions of interest in the genome, and then rigorously screen the gene-edited isogenic cell clones.

ATCC CRISPR gene-edited cell lines are:

  • Precisely gene edited
  • Engineered on commonly used tumor cell lines
  • Highly relevant to diseases and drug targets
  • Validated at genomic, transcript, and protein levels
  • Biofunctional characterization with specific inhibitors
  • Well suited for drug screening applications