Mycobacterium tuberculosis subsp. tuberculosis

27294 ^™

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Mycobacterium tuberculosis subsp. tuberculosis strain TMC 102 [H37Rv] was derived from E.R. Baldwin's 1905 human lung isolate H37 by W. Steenken. This whole-genome sequenced bacterial type strain produces culture filtrate proteins and can be used in susceptibility testing.

This strain has been assigned to Risk Group 3 - agents associated with serious or lethal human disease for which preventive or therapeutic interventions may be available. Customer Acceptance of Responsibility form required.

Product category: Bacteria
Strain designation: TMC 102 [H37Rv]
Type strain: Yes
Genome sequenced strain: Yes
Isolation source: Derived from E.R. Baldwin's 1905 human-lung isolate H37 by W. Steenken
Product format: Frozen
Storage conditions: -80°C or colder

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Documentation

BSL 3

Biosafety level 3 is applicable to any facility where work is performed with indigenous or exotic agents that may cause serious or potentially lethal disease through inhalation. Laboratory personnel must receive specific training in handling pathogenic, potentially lethal agents and must be supervised by scientists competent in handling infectious agents. ATCC determines the biosafety level of a material based on our risk assessment and as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

ATCC highly recommends that appropriate personal protective equipment is always used when handling vials. For cultures that require storage in liquid nitrogen, it is important to note that some vials may leak when submersed in liquid nitrogen and will slowly fill with liquid nitrogen. Upon thawing, the conversion of the liquid nitrogen back to its gas phase may result in the vial exploding or blowing off its cap with dangerous force creating flying debris. Unless necessary, ATCC recommends that these cultures be stored in the vapor phase of liquid nitrogen rather than submersed in liquid nitrogen.

General

Specific applications: Produces culture filtrate proteins
Susceptibility testing
Preceptrol: No

Characteristics

Comments: Parent of ATCC 35837

Handling information

Medium: This product information is not available online. Due to the nature of this product, we only provide this information to customers who have purchased this biosafety level 3 product. If you have purchased this product, please contact Technical Services for this product information.
Temperature: This product information is not available online. Due to the nature of this product, we only provide this information to customers who have purchased this biosafety level 3 product. If you have purchased this product, please contact Technical Services for this product information.
Atmosphere: This product information is not available online. Due to the nature of this product, we only provide this information to customers who have purchased this biosafety level 3 product. If you have purchased this product, please contact Technical Services for this product information.
Handling procedure: This product information is not available online. Due to the nature of this product, we only provide this information to customers who have purchased this biosafety level 3 product. If you have purchased this product, please contact Technical Services for this product information.
Handling notes: This product information is not available online. Due to the nature of this product, we only provide this information to customers who have purchased this biosafety level 3 product. If you have purchased this product, please contact Technical Services for this product information.

Quality control specifications

Verification method: Whole-genome Sequencing

History

Deposited as: Mycobacterium tuberculosis (Zopf) Lehmann and Neumann
Depositors: GP Kubica
Type of isolate: Human
Year of origin: 1934
Cross references: GenBank U06259 Mycobacterium tuberculosis ATCC 27294 catalase (katG) gene, complete cds.

GenBank L15623 Mycobacterium tuberculosis 16S ribosomal RNA and 23S ribosomal RNA genes, partial sequence.

Legal disclaimers

Intended use

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

Warranty

The product is provided 'AS IS' and the viability of ATCC^® products is warranted for 30 days from the date of shipment, provided that the customer has stored and handled the product according to the information included on the product information sheet, website, and Certificate of Analysis. For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. While other unspecified media and reagents may also produce satisfactory results, a change in the ATCC and/or depositor-recommended protocols may affect the recovery, growth, and/or function of the product. If an alternative medium formulation or reagent is used, the ATCC warranty for viability is no longer valid. Except as expressly set forth herein, no other warranties of any kind are provided, express or implied, including, but not limited to, any implied warranties of merchantability, fitness for a particular purpose, manufacture according to cGMP standards, typicality, safety, accuracy, and/or noninfringement.

Disclaimers

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

This product is sent on the condition that the customer is responsible for and assumes all risk and responsibility in connection with the receipt, handling, storage, disposal, and use of the ATCC product including without limitation taking all appropriate safety and handling precautions to minimize health or environmental risk. As a condition of receiving the material, the customer agrees that any activity undertaken with the ATCC product and any progeny or modifications will be conducted in compliance with all applicable laws, regulations, and guidelines. This product is provided 'AS IS' with no representations or warranties whatsoever except as expressly set forth herein and in no event shall ATCC, its parents, subsidiaries, directors, officers, agents, employees, assigns, successors, and affiliates be liable for indirect, special, incidental, or consequential damages of any kind in connection with or arising out of the customer's use of the product. While reasonable effort is made to ensure authenticity and reliability of materials on deposit, ATCC is not liable for damages arising from the misidentification or misrepresentation of such materials.

Please see the material transfer agreement (MTA) for further details regarding the use of this product. The MTA is available at www.atcc.org.

Permits & Restrictions

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.

MORE INFORMATION ABOUT PERMITS AND RESTRICTIONS

References

Curated Citations

Kubica GP, et al. Designation of strain H37Rv as the neotype of Mycobacterium tuberculosis. Int. J. Syst. Bacteriol. 22: 99-106, 1972.

Sonnenberg MG, Belisle JT. Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electrospray mass spectrometry. Infect. Immun. 65: 4515-4524, 1997. PubMed: 9353028

Skerman VB, et al. Approved lists of bacterial names. Int J Syst Bacteriol 30: 225-420, 1980.

Rastogi N, et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr. Microbiol. 33: 167-175, 1996.

Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes; Approved Standard. Wayne, PA. Clinical and Laboratory Standards Institute; CLSI M24-A.

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